BET proteins: Investigating BRDT as a potential target for male contraception
نویسندگان
چکیده
منابع مشابه
Small-Molecule Inhibition of BRDT for Male Contraception
A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling...
متن کاملBrdt Bromodomains Inhibitors and Other Modern Means of Male Contraception.
Compared to efficient and secure female contraception, a vasectomy and condoms are the only options for men. The choice of male contraceptive methods is limited, so contraception mainly rests on the shoulders of women. Several concepts are considered: testosterone administration--inhibiting pituitary secretion of lutropin (LH) and follicle stimulating hormone (FSH), progestogen--affecting the s...
متن کاملUrokinase-type plasminogen activator: a new target for male contraception?
Urokinase-type plasminogen activator (uPA) is closely related to male reproduction. With the aim of investigating the possibility for uPA as a potential contraceptive target, in the present work, Kunming male mice were immunized by human uPA subcutaneous injection at three separate doses for 3 times. Then the potency of the anti-human uPA antibody in serum was analyzed, and mouse fertility was ...
متن کاملThe first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation.
Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling. Its expression is restricted to the germ line, specifically to pachytene and diplotene spermatocytes and early spermatids. Targeted mutagenesis was used to generate mice carrying a mutant allele of Brdt, Brd...
متن کاملAttention Deficits in Chronic Methamphetamine Users as a Potential Target for Enhancing Treatment Efficacy
Methamphetamine (MA) is a potent, addictive psychostimulant that has dramatic effects on the central nervous system (CNS). The onset of methamphetamine use has been linked to heightened attention, and chronic methamphetamine use has been associated with deficits in different aspects of attention that can significantly persist into abstinence. Attention deficits in chronic methamphetamine users ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2020
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2020.126958